Written by Kathy Wheatley on
 April 1, 2025

Deep sleep decrease linked to higher alzheimer’s risk

A profound study from Yale School of Medicine reveals an alarming connection between inadequate sleep and the acceleration of brain deterioration linked to Alzheimer's disease.

According to CNN, A new study suggests that missing out on deep sleep phases could heighten the risk of developing Alzheimer's by causing significant brain shrinkage, particularly in brain regions vital for processing sensory and spatial information.

The research, spearheaded by Gawon Cho, a postdoctoral associate in internal medicine, examines how deficits in slow-wave and REM (Rapid Eye Movement) sleep contribute to brain changes indicative of early cognitive decline. These stages of sleep are crucial for brain health, yet often neglected.

Understanding How Sleep Influences Brain Health

Slow-wave and REM sleep are critical for various brain functions, including the clearance of brain toxins and memory processing. During an average night, adults are meant to spend between 20% and 25% of sleep in these restorative stages. Yet, studies show that over a third of American adults fall short of the standard 7-8 hours of sleep per night.

Dr. Richard Issacson, a preventive neurologist who has reviewed the study, supports its findings. He highlights that proper sleep not only supports cognitive functions but can also extend life expectancy. Specifically, good sleep habits could add nearly five years to men's lives and 2.5 years to women's lives.

The new research points to the inferior parietal region of the brain, where studies have observed significant shrinkage in people who do not attain enough deep sleep. This part of the brain handles important tasks like synthesizing sensory and visuospatial information, making it a crucial area for early detection of Alzheimer’s.

The Role of Sleep Hygiene in Preventing Alzheimer's

Enhancing sleep quality is imperative to stave off the effects of Alzheimer’s, per Cho's advice. Good sleep is characterized by feeling well-rested at least five days a week, minimal disruptions during the night, and no dependence on sleep medication.

Creating a conducive sleep environment is a part of effective sleep hygiene. This involves maintaining a consistent sleep schedule, ensuring the sleep area is cool and dark, and avoiding stimulants like alcohol before bedtime. Issacson notes that extending time in bed usually increases the duration of both REM and deep sleep.

Cho and Issacson both emphasize the significance of lifestyle changes over pharmaceutical solutions to improve sleep quality. According to Cho, “There’s no one medicine that improves overall sleep. It’s essential for individuals to actively work toward better sleep practices.”

Practical Steps to Enhance Sleep Quality

The revelations from the study underline the urgency of addressing sleep quality as a public health issue. Given the strong linkage between sleep deprivation and Alzheimer’s risk, the emphasis is now shifting towards more robust public health strategies to promote better sleep habits among populations.

Issacson suggests a more extended period in bed as a simple, practical approach for most adults to acquire more deep sleep and REM stages, which are so vital to brain health. "The more time you are in bed, the more a person sleeps, and generally speaking, the longer a person sleeps, the more REM and deep sleep they will get," he explains.

The study has profound implications, suggesting that intervention through improved sleep quality could play a significant role in delaying, if not preventing, the onset of Alzheimer's disease in at-risk populations.

Educational Efforts and Future Research Directions

This study sheds light on the preventive strategies against Alzheimer's disease, focusing on the manageable aspect of daily life: sleep. Researchers expect further research to explore in more depth how these findings can be implemented in daily medical practice and public health policies.

As the scientific community continues to unravel the mysteries of Alzheimer's, this study adds a crucial piece to the puzzle: the undeniable effect of sleep on brain health. With ongoing research, the hope is to formulate strategic interventions that can substantially alter the course of this debilitating disease.

Ultimately, the battle against Alzheimer's might just begin with a good night's sleep. As research evolves, so does the understanding that sleep is not just a restorative necessity but a robust defense against the decay of cognitive functions.

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About Kathy Wheatley

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