Written by Kathy Wheatley on
 March 10, 2025

Luxembourg royal, Prince Frederik, passes at 22 after battling rare disease

The royal family of Luxembourg has announced the death of 22-year-old Prince Frederik, who fought a relentless battle against a rare genetic disorder known as POLG Mitochondrial disease.According to the US Sun, Prince Frederik passed away in Paris on March 1, following a prolonged struggle with a condition that causes multiple organ failure.

Prince Frederik was born in Aix-en-Provence, France, and had spent his early years in London before moving to Geneva, Switzerland, where he pursued his education at Ecole Eden Primary School and St George’s School in Clarens next to Montreux.

The young prince was first diagnosed with POLG Mitochondrial disease at the age of 14, a disorder characterized by the depletion of cellular energy, leading to multiple organ failure.

Prince Frederik’s Early Life and Education

Frederik’s interests were diverse; he enjoyed music, film, nature, fossils, and gastronomy, reflecting a vibrant spirit despite his health challenges. Diagnosed during his formative teenage years, the disease did not hinder his creative and intellectual pursuits.

Eventually, Frederik relocated to Geneva for his education, which proved foundational in his personal and professional life.

The Founding of the POLG Foundation

In response to his condition, Prince Frederik founded the POLG Foundation, with a mission to increase awareness and fund research into the disease.

He also took on the role of Creative Director within the foundation, actively participating in its activities and initiatives.

Despite health setbacks, his involvement in the foundation showcased his dedication to helping others afflicted with similar conditions.

Prince Frederik's Family and Their Support

Frederik was a beloved member of his family, sharing close bonds with his brother Alexander and sister Charlotte, as well as his parents, Prince Robert and Princess Julie of Nassau. His father, Prince Robert, is the first cousin of Grand Duke Henri of Luxembourg.

His family often described him as their “superhero,” a testament to his resilience and strength in facing life’s adversities.

Prince Robert's heartfelt announcement reflected deep familial ties and the profound impact Frederik had on their lives.

Final Days and Lasting Impact

In his final days, despite increasing health complications, Frederik demonstrated remarkable spirit. He was recently hospitalized for pneumonia and a severe infection, which ultimately exacerbated his condition.

His father shared how, even in his last moments, Frederik's compassion and humor shone through. He fondly recounted Frederik’s last interactions with his family where he individually said his goodbyes, reflecting each person's significance in his life.

This included heartfelt farewells and shared memories that underscored his enduring love and the strength of his character.

Prince Frederik's Legacy in Medical Awareness

The legacy of Prince Frederik extends beyond his royal heritage and into the realm of medical research and public awareness, primarily through his work with the POLG Foundation.

His contributions have paved the way for better understanding and potential therapies for others suffering from POLG Mitochondrial disease.

The profound impact of his endeavors remains a beacon of hope and a testament to his enduring spirit and commitment to a cause greater than himself.

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About Kathy Wheatley

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